电子邮件: Kristopher.施瓦布@ljzd.net                    

办公室: Science Building 287L

研究 Interests: 分子, 遗传, and epi遗传 regulation of gene expression during embryonic development, 分化, 和疾病.

My research interests are broadly focused upon the mechanisms of gene regulation in embryonic development, cellular 分化, 和疾病. The transcriptional changes induced by these processes occur due to the expression of powerful cell signaling molecules and transcription factors which control cellular function. Developmental gene regulatory networks not only pattern the developing embryo by regulating cellular 分化, but also are erroneously activated or repressed in tissue injury exacerbating the disease or inducing cancer.  By studying gene function in the context of these different biological processes, we can better understand the actions of genes and their ability to prevent or cause human disease. 

Selected Publications and Abstracts/Presentations:

施瓦布基米-雷克南, Smith G, 杜丝勒GR.  (2013).  Arrested Spermatogenesis and Evidence for DNA Damage in PTIP Mutant Testes.  Developmental 生物学 373: 64-71.

施瓦布基米-雷克南, Patel SR, 杜丝勒GR  (2011).  The role of PTIP in class switch recombination and long range chromatin interactions at the immunoglobulin heavy chain locus.  Mol细胞生物学. 31: 1503-1511.

Daniel JA, Santos MA, Wang Z, Zang C, 施瓦布基米-雷克南, 扬科维奇米, Filsuf D, 陈HT, Gazumyan一, Yamane一, 曹YW, 太阳HW, 通用电气K, 彭女士, 生理压力MC, 卡塞拉R, 杜丝勒GR, 赵K, 压力的一个.  (2010).  PTIP promotes chromatin changes critical for immunoglobulin class switch recombination.  Science 20: 917-923.

施瓦布基米-雷克南, Patterson LT, Hartman HA, 首歌, Lang RA, Lin X, Potter SS. (2007).  Pygo1 and Pygo2 roles in Wnt signaling in mammalian kidney development.  BMC医学杂志. 四月10:5:15.

首歌, 施瓦布基米-雷克南, Patterson LT, Yamaguchi T, Lin X, Potter SS, Lang RA. (2007). Pygopus2 has a critical, Wnt pathway-independent function in lens induction.  Development 134: 1873-85. 

施瓦布K, Patterson LT, Aronow BJ, Hartman HA, Liang H, Potter SS. (2006).  Comprehensive gene expression analysis of normal and HoxA11/D11 null developing metanephric kidneys.  Dev Biol 293: 540-54.

施瓦布K, Witte DP, Aronow BJ, Devarajan P, Potter SS, Patterson LT.  (2004).  Microarray analysis of focal segmental glomerulosclerosis.  Am J Nephrol 24: 438-47.

施瓦布K, Patterson LT, Aronow BJ, Luckas R, Liang H, Potter SS.  (2003).  A catalog of gene expression in the early developing metanephric kidney.  Kidney Int 64:1588-1604.